Best 5-HTP (Griffonia Simplicifolia) Supplements Explained

Symptoms of our busy lifestyle sometimes occur at the moment but in most cases, they are the result of chronic fatigue, stress, and congestion. It is the accumulation of fatigue that may lead to more serious consequences and such traversal would be more difficult.

Signs of continuous exhaustion are - insomnia, nervous attacks, depression, anxiety, pain and acts of aggression. The market offers a wide range of medicines and food supplements but one substance is particularly popular. This is a 5-HTP amino acid (5-hydroxytryptophan).

Griffonia is a bush that grows in West Africa. The plant is known as the richest natural source of the 5-hydroxytryptophan amino acid. It constitutes 20% of the mass of the bush. In traditional African medicine, Griffonia is used as an aphrodisiac and antibiotic. It also helps with diarrhea, vomiting, and stomach pain.

The leaves of the plant can use for faster wound healing. Nowadays the plant is used for the treatment of anxiety, nervousness, depression, insomnia, migraine, headache, and appetite regulation. These Griffonia positive effects are due to the 5-HTP amino acid. The main component of the Griffonia is the 5-hydroxytryptophan amino acid.

5-HTP is a major precursor of the neurotransmitter serotonin, known as the hormone of happiness. 5-HTP has the ability to cross the blood-brain barrier. 5-HTP is one of the most effective agents for increasing the levels of serotonin. This is the reason why it is used as a means of increasing serotonin levels in medical studies.

Top 10 5-HTP Supplements Reviewed

NOW Foods 5-HTP 100 mg Overview

5-HTP supplement, the intermediate metabolite between the amino acid L-Tryptophan and Serotonin, is extracted from the bean of an African plant Griffonia simplicifolia.

  • Neurotransmitter support;
  • Natural source;
  • Supports positive mood;
  • GMP quality assured;
  • A dietary supplement;
  • Vegetarian formula.

How This 5-HTP Supplement Product Will Help Me

NOW Foods 5-HTP is a supplement that will provide you the 5-hydroxytryptophan amino acid. That acid is necessary for the synthesis of the serotonin neurotransmitter.

Serotonin is essential for the central nervous system and is responsible for controlling anger, aggression, body temperature, mood, sleep, appetite, sexuality, and others. Besides being indispensable in the brain, when insufficient levels in the body, serotonin saturates the blood and the gastrointestinal tract.

It is also called "the hormone of happiness." When lacking, depressions and nervous disorders start to occur. Libido and self-esteem get decreased. Aggressiveness increases. The appetite for sweet gets irresistible. 

The stomach becomes irritable. Researches associate it with the processes of aging and the ability to remember and learn. The busy lifestyle and stress decrease serotonin levels. Its deficiency can be very easily recognized. The product is of guaranteed quality and official origin from a leading manufacturer. Get yourself relaxation, sleep, excellent libido and self-esteem.

Suggested Use

As a dietary supplement, take 1 vcap daily, preferably on an empty stomach at bedtime. Consider taking this product in combination with NOW Valerian Root, Relora, and Pantothenic Acid.

How Does Nature's Way 5-HTP Work

Nature's Way 5-HTP 5-hydroxytryptophan is a natural substance produced in the body from the essential amino acid tryptophan, which gets into the body through food.

5-hydroxytryptophan (5-HTP/Griffonia Simplicifolia) is converted into serotonin in the brain. Serotonin, also known as 5-hydroxytryptamine or "the hormone of happiness" transmits nerve impulses between the brain cells. 

It is mainly contained in the brain, where it is synthesized, as well as in the red blood cells (RBCs). The serotonin levels in the body are of key importance in the mood, appetite, sexuality and more.

The low levels of serotonin inevitably lead to severe depressive episodes, anxiety states and panic and anxiety attacks, low self-esteem, insomnia, headaches, and others. Nature's Way 5-HTP is a natural product that does not cause addiction. Its intake leads to increased levels of serotonin.

The active ingredient of 5-HTP supplements in 5-hydroxytryptophan is extracted from the seeds of African plant Griffonia simplicifolia, as the purity of the composition in each tablet is guaranteed. Each tablet provides 100 mg of the active substance in the guaranteed pollutant-free environment.


The intake of 5-HTP in combination with other additives and/or prescribed medication for improving mood is not recommended.

Suggested Use

Recommendation: Take 1-2 tablets three times daily with meals, or as recommended by a healthcare professional.

Time Release 5-HTP

by Natrol

Natrol: 5-HTP Time Release 200 mg, 30 tabs (2 Pack)

What Is Natrol Time Release 5-HTP 200 mg

5-HTP Time Release by Natrol is a natural plant-based product. It is the source of this amino acid that has the ability to naturally increase the serotonin levels in the body (it is a direct precursor of its).

Serotonin is a chemical mediator in the body that regulates the processes associated with emotions, behavior, appetite, sleep and mental activity.

How This Product Will Help Me

The regular use of 5-HTP supplements Time Release helps maintain a positive view of life, good mood, effective relaxation, tranquility, and excellent control over appetite.

The 5-HTP (Griffonia Simplicifolia) Time Release tablets by Natrol  (200 mg) provide a controlled gradual release of the active ingredient 5-HTP for more than 15 hours in order to maintain the effect throughout the day.


The intake of 5-HTP in combination with other additives and/or prescribed medication for improving mood is not recommended.

Suggested Use

Take 1 tablet, one time daily, with food. Do not exceed the recommended dose.


by Jarrow Formulas

Jarrow Formulas 5-HTP, Brain and Memory Support, 100 mg, 60 Caps

What Is Jarrow Formulas 5-HTP Used For

Jarrow Formulas 5-HTP (5-hydroxytryptophan) is an extract from the seeds of Griffonia simplicifolia, a plant that is found along the coast of West Africa.

5-HTP or "Hydroxy L-Tryptophan" (5-Hydroxytryptophan) is a naturally occurring amino acid and is a precursor and metabolic intermediate product in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan.

This is a widely used supplement for assisting programs for weight control or counteraction to daily stress as well as conditions such as PMS (premenstrual syndrome), migraine, depression, anxiety, insomnia.

How Does This 5-HTP Product Act

The 5-HTP supplement increases the production of serotonin. The serotonin levels in the nervous system are essential for so many aspects of our daily lives.

Serotonin is responsible for the feeling of well-being and satisfaction, as well as for healthy sleep. Obesity, premenstrual syndrome, migraine, depression, anxiety, insomnia, and addiction are conditions associated with low levels of serotonin.

Serotonin plays an important role in the controlling anger, aggression, body temperature, mood, sleep, sexuality, appetite, and metabolism.


The intake of 5-HTP supplements in combination with other additives and/or prescribed medication for improving mood is not recommended.

How to Take 5-HTP Supplements

Take 1 tablet, one time daily, with food. Do not exceed the recommended dose.


  • Positive mood support;
  • Promotes relaxation;
  • Gluten, wheat & dairy-free;
  • Suitable for vegetarians;
  • Kosher parve;
  • Dietary supplement.

What Are the Benefits of 5-HTP Usage

5-HTP takes part in the formation of serotonin (has an important role in the melatonin synthesis). 5-HTP is derived from Griffonia Simplicifolia and improves the sleep and mood. It regulates appetite and body weight.

Solgar 5-HTP provides natural-source 5-HTP that is peak X-free. 5-HTP supports your brain's production of serotonin. This formulation helps to promote both a positive mood and a state of relaxation.


The intake of 5-HTP supplements in combination with other additives and/or prescribed medication for improving mood is not recommended.

Suggested Use

As a dietary supplement for adults, take one (1) to two (2) vegetable capsules daily, between meals, or as directed by a healthcare practitioner.

What Is Doctor's Best 5-HTP 100 mg

Best 5-HTP supplement 100 mg (5-hydroxy L-tryptophan) is a natural metabolite of amino acid tryptophan that often occurs naturally within the body. Best 5-HTP 100 mg can be converted within the brain easily to serotonin‚ that is a neurotransmitter substance mainly found between neuron at the junctions.

Best 5-HTP 100 mg often helps in maintaining mental as well as emotional well-being while promoting healthy sleep. All Best 5-HTP 100 mg are based on science-based nutrition containing a compound extracted mostly from the Griffonia simplicifolia plant seeds. 

When using it, you can use to treat cases of depression, anxiety, low self-esteem and insomnia that are the main symptoms of very low levels of serotonin in the body. When you use it, you will be able to get adequate B vitamins and tryptophan in the diets thus producing sufficient serotonin.

Doctor's Best 5-HTP 100 mg Benefits

  • Helps in dealing with Weight Loss: Excessive weight gain can be a problem for you when you have low body metabolism. However, with 5-HTP 100 mg, you will be able to improve your health remarkably by enhancing metabolism to lose more weight thus transforming your weight. For instance, a research study has found that taking a 5-HTP supplement can help you lose 10.3 pounds in just three months.
  • Treating cases of Insomnia: 5-HTP 100 mg can help your body in the production of melatonin from extra serotonin that is left especially at the end of a day. This has been the main reason why many people are frustrated, depressed when they want to sleep. Using 5-HTP 100 mg can help you sleep quicker and more deeply when you had a bad day.
  • Cure cases of Depression: With 5-HTP 100 mg, you can be sure that you will reduce cases of depression in your life while enhancing it remarkably. In many cases, it works as a calming, soothing, uplifting, or just like an anti-depressive drug.

What Are the Sports Benefits for a Person to Use Doctor's Best 5-HTP 100 mg

Any person who does sports always suffers from the problem of anxiety. However, the best 5-HTP 100 mg can help you in managing anxiety easily whenever you want to excel in whichever type of sport that you would need.

5-HTP 100 mg can be a good option for people suffering from both anxiety and depression. Many people with social anxiety can relieve themselves by taking 50 mg of 5-htp every day for about 3 to 4 days. In the end, you will concentrate on your sport thus doing better in one way or the other. 

How and When to Take Doctor's Best 5-HTP 100 mg

According to a dietary supplement, you should ensure that you take one capsule just two or three times a day, with or even just without food.

Also, you must ensure that you follow the given instructions whenever you need to take it if you want to find the best results upon using it. In case of side effects, you can always be contented with the quality whenever you want to enhance your health.


by California Gold Nutrition

California Gold Nutrition 5-HTP Mood Support Griffonia Simplicifolia Extract from Switzerland 100 mg 90 Veggie Caps, Fish-Free, Gluten-Free, Milk-Free, Peanut Free, Soy-Free, Shellfish Free, CGN

California Gold Nutrition 5-HTP Benefits

Here are some of the benefits we can expect from 5-HTP:

Treats headache

5-HTP has as well been used for treating prolonged headaches such as tension headaches, juvenile headaches, and migraines. These are circumstances which may be associated with low serotonin. 5-HTP has the capacity to decrease the severity and regularity of these conditions, with little side effects related to other chronic headache treatments.

Controls Fibromyalgia

One of the key benefits of 5-HTP supplements is the aid that it gives for individuals with fibromyalgia. It helps to improve sleep and as well as reduce depression, pain, stiffness, and anxiety - all of which are signs of this disorder.

Supports Weight Loss

5-HTP may do wonders for people who would like to lose weight. An appetite that is too healthy may be affected by low serotonin levels, therefore, taking in 5-HTP can stabilize these levels. Also, 5-HTP can reduce your food intake by forming a feeling of fullness. It can increase the secretion of the hormone leptin (an appetite regulator) hence resulting in better weight loss.

Improves the life of individuals affected by Bipolar Disorder

Medical studies have revealed the anti-depressant result of 5-HTP supplement for those suffering from bipolar II disorder. 5-HTP can relieve and reduce to improve the overall quality of life of bipolar victims.

Controls Insomnia

5-HTP promotes good sleep. Indeed, its supplement is perceived to be enhanced than melatonin in promoting good sleep and relieving sleeplessness. It is capable of increasing the quality of sleep without after-effect or drugged moods which are commonly present in sleeping tablets and narcotics.

Moderates Depression

A lot of people have already valued the benefits of 5-HTP against depression. It is real as anti-depressants in the cure to moderate unhappiness.

Regulates Anxiety

Low serotonin levels can cause abnormal unease. With 5-HTP, there is a better chance for serotonin to go back to its natural level, henceforth you can feel normal again.

What Are the Sports Benefits for a Person to Use 5-HTP

California Gold Nutrition 5-HTP aids to normalize serotonin activity in Sports participant’s body and consequently may reduce appetite, positively affect mood and help regulate the sleep cycle. 

Also, 5-HTP is used in treatment for muscle pains caused by stress (Fibromyalgia) which may attack a sports participant.

How and When to Take California Gold Nutrition 5-HTP

The best 5 HTP prescriptions ought to range from about 50 to 400 mg. Supplements are available in 5-HTP 50 mg and 5-HTP 100 mg tablets. For depression, the standard dosage will involve taking in a capsule or two once to four times every day for 50 mg 5 HTP pills. 

Again, while taking three tablets in divided doses are only recommended for 100 mg capsule. Lesser doses are commonly required for treating sleeping disorders and for weight loss. 

It is also good that you consult with a healthcare professional to be informed about which dose is best for your needs. Normally, it is advised that you begin with small dosages and slowly increasing when no consequence is felt.


5-HTP is not used for any illness or ailment. Though, many people love that it is an effective dietary enhancement for supporting a healthy mood.


by Source Naturals

SOURCE NATURALS Serene Science 5-HTP 100 Mg Capsule, 120 Count

What Is Source Naturals 5-HTP 100 mg

5-HTP ( commonly known as l-5-Hydroxytryptophan) is a common intermediate that helps in a natural conversion of essential tryptophan, an amino acid to serotonin within the body.

When you are using Source Naturals 5-HTP 100 mg, your body will be able to adjust naturally through a neurotransmitter substance to enhance your life faster and easier. Also, this natural 5-HTP supplement, containing 100 mg per capsule, can help you in keeping mental or emotional well-being to promote that healthy sleep.

In many cases, medics have always advised patients to use it when treating depression, higher levels of anxiety, low self-esteem as well as insomnia. These are always symptoms of low serotonin levels in the body.

Before you use it, you should ensure that you get help from a certified medical specialist who will advise you accordingly whenever you want to improve your health with the Source Naturals 5-HTP 100 mg.

What Are the Benefits of Source Naturals 5-HTP 100 mg

The benefits are as follows: 

Reduce Depression

When using Source Naturals 5-HTP 100 mg, you are in a position of reducing levels of depression within your life easier. Why would you do so? Source Naturals 5-HTP 100 mg often works as an anti-depressive drug through calming, soothing, and uplifting your spirit much faster. 

Enhance a Healthy Weight Loss

If you are a person who has gained a lot of weight, Source Naturals 5-HTP 100 mg should be your choice while addressing the problem. Upon using it, you will improve your metabolism of the body thus helping you in burning excessive fasts stored in the body. Ultimately, Source Naturals 5-HTP 100 mg will assist you in keeping check your weight much easier when compared to many other weight loss products sold in the market with lots of side effects.

Reducing Insomnia

Source Naturals 5-HTP 100 mg is a drug that is important in melatonin production from extra serotonin commonly left at the end of the day in your body. Why say so? In case you are frustrated or even depressed, and you want to sleep, you can use Source Naturals 5-HTP 100 mg since it will help increase your ability to sleep much faster. 

What Are the Sports Benefits for a Person to Use Source Naturals 5-HTP 

In case you are a sportsman who would love to excel in the kind of sport your love, Source Naturals 5-HTP 100 mg can help you improve your focus while reducing anxiety.

Why say so? During the competition in sports, the levels of anxiety often increase remarkably, which needs a countermeasure when dealing with it. Source Naturals 5-HTP 100 mg can help you lower the levels of anxiety that will enable you to excel in the sport much higher. 

How and When to Take Source Naturals 5-HTP

When using Source Naturals 5-HTP 100 mg, you will get 60 capsules that you can take in a period of 2 to 3 months depending on the advice from a doctor or any other medical specialist such as a pharmacist.

You can use one capsule 2-3 three times daily. You can take them with or without food. You should follow the guidelines well whenever you want to improve your life.


by Thorne Research

Thorne Research - 5-Hydroxytryptophan (5-HTP) - Serotonin Support for Sleep and Stress Management - 90 Capsules

What Is Thorne Research 5-Hydroxytryptophan

5-Hydroxytryptophan(5-HTP) is a product of Thorns Research and is used as a health supplement. 5-HTP supplement is an essential amino acid that is produced in the body naturally during tryptophan breakdown.

5-HTP is an intermediate metabolite that is produced during the production of serotonin. The serotonin hormone regulates various body factors such as mood, sleep, and appetite.

Supplementing with the Thorne Research 5-HTP enhances the production of this hormone making it available in the body in the right amounts. 5-HTP is produced through the extraction of seeds from an African climbing shrub known as Griffonia simplicifolia.

Thorne Research 5-Hydroxytryptophan Benefits

  • Increases serotonin production: This leads to better stress management thereby leading to better sleeping patterns. It also reduces sugar cravings. Other benefits of serotonin are improved sexual desire, improved social behavior, memory, and digestion. 5-HTP provides all these.
  • Safe to use with other foods: 5-Hydroxytryptophan does not compete with other important amino acids in the body. This makes it safe to be taken together with other meals as its effectiveness is not affected.
  • Vitamin B6: This product has vitamin B6 to optimize brain and nervous system activities. The vitamin also plays a major role in protein metabolism.

The Sports Benefits for a Person to Use Thorne Research 5-HTP

  • Motivation: 5-HTP enhances the production of neurotransmitters such as serotonin and dopamine which highly affect the mood. Many athletes have been known to suffer from low serotonin levels which may cause depression. Serotonin improves the mood making athletes happier individuals and more motivated to win.
  • Fatigue and Sleep: With the facilitation of serotonin production, 5-HTP reduces the discomforts associated with fatigue. Most athletes are usually fatigued after practice or after games. 5-HTP will allow them to better cope with it. Furthermore, serotonin also facilitates sleep and therefore you wake up rested after sleeping through the night.
  • Muscular functioning: 5-HTP as pyridoxal 5'-phosphate which is an active form of vitamin B6 which further facilitates serotonin production. This vitamin is important for heart health, proper muscular functioning as well as normal brain and nervous system activities. Vitamin B6 is important for hard-training athletes especially because it enhances protein metabolism.
  • Focus: Vitamin B6 in the 5-HTP promotes the formation of neurotransmitters, particularly dopamine and epinephrine. These influence the mood, energy, and ability to focus. Athletes are therefore able to benefit from increased focus and intensity.
  • Pain endurance: 5-HTP reduces the symptoms of fibromyalgia which is a disease that is associated with sensitivity to pressure and pain. 5-HTP supplements reduce the symptoms such as an extreme feeling of pain, stiffness, and insomnia. For athletes with this disorder, 5-HTP supplements are quite important.

How and When to Take Thorne Research 5-HTP

5-HTP is a capsule that is taken orally. It is absorbed effectively into the body, with about 70% of it being absorbed into the bloodstream. It is recommended to take one or two capsules three times a day or as recommended by your healthcare practitioner.

Consultation with a doctor is advised for pregnant or lactating mothers before the use of 5-HTP.  Get yourself this supplement and enjoy all these benefits.

What Is 5-HTP (Griffonia Simplicifolia)

Griffonia is a bush that grows in West Africa. The plant is known as the richest natural source of the 5-hydroxytryptophan amino acid. It constitutes 20% of the mass of the bush. It is assumed that Griffonia may contain other bioactive components but the plant is not sufficiently studied and there is no detailed scientific basis.

In traditional African medicine, Griffonia is used as an aphrodisiac and antibiotic. It also helps with diarrhea, vomiting, and stomach pain. The leaves of the plant can use for faster wound healing.

Nowadays the plant is used for the treatment of anxiety, nervousness, depression, insomnia, migraine, headache, and appetite regulation. These Griffonia positive effects are due to the 5-HTP amino acid. The main component of the Griffonia is the 5-hydroxytryptophan amino acid.

Its concentrations are up to 10% in seeds, 1.2% in the leaves and up to 0.2% in the stem. Seeds are the main source of standardized extracts of the industry. Besides 5-HTP, Griffonia contains small amounts of lectins whose content is relatively low at this stage and only be used for scientific purposes.

How Do Griffonia and 5-HTP Work

Test and research results confirm that the oral intake of Griffonia successfully increases the levels of 5-HTP. Spraying five times a day of 30.72 mg Griffonia provides 7.68 mg of 5-HTP according to studies. Thus, a daily dose of 40 mg 5-HTP increases the concentration of the amino acid of 137% within 24 hours.

5-HTP is a major precursor of the neurotransmitter serotonin, known as the hormone of happiness. 5-HTP and Griffonia are preferred over L-tryptophan as a source of serotonin, for the greater part of the tryptophan are converted to niacin (vitamin B-3).

5-HTP has the ability to cross the blood-brain barrier. Another advantage of the 5-HTP is that the amino acid fails to overcome the protective mechanism of self-regulation of L-tryptophan and overcomes the enzymes that degrade tryptophan and inhibit the synthesis of serotonin.

5-HTP is one of the most effective agents for increasing the levels of serotonin. This is the reason why it is used as a means of increasing serotonin levels in medical studies.

Proven Benefits in People:

1) Appetite regulation

Taken alone or in combination with other ingredients, Griffonia increases satiety of appetite at every meal. Even small doses of 2.6 mg per meal are effective.

The mechanism is not related to suppressing hunger and increasing the satisfaction of food. The effect is stronger for women, although there is one study that found a positive effect on both sexes.

Although the end result is a decrease in the amount of food, 5-HTP is not used to suppress appetite. It has to be noted that all tests are performed on people who overeat regularly.

2) Carbohydrates cravings

5-HTP suppresses insatiable appetite for carbohydrates but the possible mechanism is explained by the increasing serotonin levels. Two studies have found that high daily doses of 5-HTP reduce overall calorie intake. 

A third study has found that 75% of the reduced calories come from carbohydrates. Similar results occurred in intake of 750 mg of 5-HTP daily by diabetics.

3) Depression

There is no evidence that monotherapy with 5-HTP may improve the condition of depression at this stage.

On the other hand, supplementing the drug Carbidopa with an average dose of 200 mg of 5-HTP significantly improves in 43.4% of patients. It is possible that 5-HTP enhances the effects of other similar drugs.

4) Sleep

Combining GABA with 5-HTP shows a drastic decrease in time for falling asleep and improves the quality of sleep by the standards PSQI (Pittsburg sleep quality index).

5) Stress

There are potential but promising benefits related to the reduction of stress after relationship separation in young and non-stressed individuals. 

An independent study showed dramatic improvement after 6 weeks of dosing with 60 mg Griffonia (12. 8 mg of 5-HTP) a day, but the quality of the research indicates questionable results.

6) Alcoholism

The combination of 5-HTP with L-glutamine and L-phenylalanine in hospitals shows that 40-day therapy eliminates all the symptoms of alcohol-dependent patients. 

The results are much better than the placebo ones.

7) Panic

The use of 200 mg of 5-hydroxytryptophan improves dramatically all panic attacks in healthy individuals and in patients with panic disorders. The effect is much stronger in subjects suffering from diseases. 

Similar results can be found also in children, a dose of 2 mg/kg of 5-HTP for a period of 20 days in children aged 3.2 to 10.6 years demonstrated more than 50% midnight terror frequency regulation in 93.5% of the subjects. 

There is n 83.9 % improvement even six months after taking 5-HTP.

How to Use 5-HTP

At this stage, there are no detailed established optimal doses for people. The appropriate dose for people will be determined by the dose given to animals. It was found that the lowest effective dose in rats was 25 mg/kg extract Griffonia, which is 4-5 mg/kg 5-HTP.

If the dose is adjusted to human weight, we conclude that the lowest effective doses are:

  • 55 mg of 5-HTP per 68 kg-person;
  • 70 mg per 90 kg-people;
  • 90 mg per 112 kg-people.

5-HTP is not influenced by taking any kind of food, so it does not matter whether used with food or on an empty stomach. The intake of food is important if you are looking for reducing appetite effect. 

It is recommended that 5-HTP can be taken with food because it enhances the quench of appetite by the consumed meal and does not suppress hunger as thermogenic do.

Side Effects and Contraindications

It was found that lectins in Griffonia are resistant to proteolysis. Studies on pigs and rats conclude that these lectins bind to endothelial cells and stick to the walls of the small intestine.

Although not proven in any way, there is a risk of the potential intake of Griffonia by people with celiac disease. It is believed that no Griffonia or 5-HTP lead to serious side effects. 

Increased nausea by the usage of high doses is observed in most cases. This effect disappears with dose reduction or passes with constant use for a short period of time. Intake of 5-HTP increases the impact cortisol within the next 3 hours in patients with panic deviations.

Possible Combinations with Other Ingredients

Regular use of 5-HTP may result in the reduction of dopamine levels. On the other hand, high doses of L-tyrosine can lead to a shortage of 5-HTP and serotonin. 

To avoid this effect, most experts recommend concomitant, use of 5-HTP with L-tyrosine or L-phenylalanine. Another possible mechanism for preventing dopamine deficiency is the combination of 5-HTP with L-DOPA or Mucuna.

5-HTP may be combined with GABA, melatonin, L-tryptophan, and niacin without possible interactions. The main objective is to improve sleep, relieve and counteract anxiety and depression.

Dopamine decarboxylase enzyme enhances the synthesis of serotonin from 5-HTP.  It has been found that catechins in green tea, including EGCG, inhibit the activity of the enzyme and is therefore not recommended to combine 5-HTP with green tea.

Combining 5-HTP with medication is recommended only after consulting a doctor. Intake of 5-HTP with SSRI (serotonin reuptake blockers) is not recommended. The possible combination can be even fatal.

Where to Find 5-HTP

5-HTP is a popular dietary supplement and is available as an extract from the seeds of Griffonia simplicifolia. All extracts on the market are standardized to a high content of 5-HTP.

Most products contain a dose of 50 mg, 100 mg and less than 200 mg per capsule.  Similar products are NOW Foods 5-HTP 50 mg and 5-HTP 100 mg

Griffonia is often used in complex formulas, most commonly in formulas for improving sleep, for counteracting depression and less as a fat burner.

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 written by 

Brains $ Gainz


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